Custom Peptides
Cayman Chemical N-Alyl- -SKF 38393hydrob 10mg
A dopamine D1 receptor partial agonist; selective for dopamine D1 over D2 receptors in radioligand binding assays (Kis = 302 and 5,250 nM, respectively); reduces food intake in rats (ED50 = 3.6 mg/kg); reduces cocaine and food self-administration in squirrel monkeys from 0.1-10 mg/kg
Cayman Chemical DIpsacosIde B 10mg
A triterpenoid saponin with hepatoprotective activity; enhances acetaminophen-induced autophagy and inhibits acetaminophen-induced apoptosis in HepG2 cells at 0.5 µM; increases survival in a mouse model of acetaminophen-induced acute liver failure at 50 mg/kg
Cayman Chemical 27-hydroxy Cholestenon 10mg
An oxysterol; levels are increased in Cyp46a-/- mouse brain; has been used as an intermediate in the synthesis of dafachronic acid ligands for the DAF-12 nuclear hormone receptor
Cayman Chemical BetulnIc ACD propargyl St 10mg
An alkyne derivative of betulinic acid; has been used in click chemistry reactions for the synthesis of cytotoxic anticancer betulinic acid derivatives
Cayman Chemical 3 4MethylendIoxy PV9hydro 10mg
A cathinone whose physiological and toxicological properties are not known
Cayman Chemical DIhomoLInolenIc AcId 10mg
An elongation product of γ-linolenic acid (18:3), rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4); metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins; can reduce atopic dermatitis and atherosclerosis when added to the diet of mice
Cayman Chemical 5-hydroxy ThIabendazole 10mg
A major metabolite of thiabendazole; has no effect on the growth of third-stage A. caninum larvae
Cayman Chemical PPACKtrIfluoroacetAT salt 10mg
A synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM); used as an anticoagulant (100 μM)
Cayman Chemical Butenoyl PAF 10mg
A product of the oxidative decomposition of 2-arachidonoyl phospholipids; 10-fold less potent than PAF as a PAF receptor agonist, but present in amounts 100-fold greater
Cayman Chemical ArachIdonyl-L-carnItInchl 10mg
An acylcarnitine formed from carnitine conjugated to arachidonic acid; may be useful as a marker of mitochondrial dysfunction
Cayman Chemical 2Omethyl PAF C18hydrAT 10mg
A synthetic PAF analog which contains an ether-linked methyl group at the sn-2 position; decreases plasma membrane fluidity, inhibits tumor cell invasiveness, and causes the release of large quantities of NO by a pathway involving activation of NOS
Cayman Chemical SynthetIc -KavaIn 10mg
A kavalactone with diverse biological activities; a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors (EC50s = 25 and 59 µM in the presence and absence of 300 µM (+)-kavain); reduces growth of WPMY-1 prostate cancer cells (IC50= 5.2 UG/ml); reduces LPS-induced TNF-α production in primary murine macrophages; reduces hind paw swelling and TNF-α production in a mouse model of collagen-induced arthritis; reduces acetic acid-induced abdominal constrictions in mice (ED50= 15.71 mg/kg)
Cayman Chemical FngchInolIn 10mg
An alkaloid; inhibits sheep COX activity and decreases IL-6-induced proliferation of MH60 mouse hybridoma cells (IC50s = 129 and 3.7 µM, respectively); reduces cyanide-induced increases in secreted glutamate levels and cell death in primary neonatal rat cerebellar granule neurons at 1 and 10 µM; decreases proliferation of PC3 human prostate cancer cells by 63 and 86% at 20 and 30 µM, respectively; reduces tumor cell growth in a PC3 mouse xenograft model at 5 mg/kg per day for 12 days
Cayman Chemical FenbrutInIb 10mg
A BTK inhibitor (Kis = 0.91, 1.6, 1.3, 12.6, and 3.4 nM for wild-type BTK, BTKC481S, BTKC481R, BTKT474I, and BTKT474M, respectively); selective for BTK over a panel of 287 additional kinases at 1 µM; inhibits anti-IgM antibody-induced BTK phosphorylation in B cells (IC50 = 3.1 nM), as well as anti-IgM- or CD40L-induced proliferation of B cells (IC50s = 1.2 and 1.4 nM, respectively); reduces ankle thickness and cartilage damage in a rat model of collagen-induced arthritis
Cayman Chemical KIspeptIn234trIfluoroacet 10mg
A peptide kisspeptin receptor antagonist; inhibits kisspeptin-10-induced inositol phosphate production in CHO cells expressing the human kisspeptin receptor (IC50 = 7 nM) and kisspeptin-10-induced firing of isolated mouse GnRH neurons; inhibits pulsatile GnRH secretion in pubertal female rhesus monkeys; inhibits kisspeptin-10-induced luteinizing hormone secretion in adult male rats and mice