Custom Peptides
ABclonal Technology Phospho-IRAK4-Thr345/Ser346 Rabbit pAb
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Cayman Chemical ProstaglndIn I2sodIM salt 10mg
PGI2 is an unstable COX metabolite detected first in vascular endothelial cells.{502,443,933} It elevates platelet cAMP and is a potent vasodilator and inhibitor of human platelet aggregation with an IC50 value of 5 nM.{4375} PGI2 is stable in basic buffers (pH=8), but it is rapidly hydrolyzed to 6-keto PGF1α in neutral or acidic solutions. The half-life is short both in vivo and in vitro, ranging from 30 seconds to a few minutes. PGI2 is administered by continuous infusion in humans for the treatment of idiopathic pulmonary hypertension.{5466}
Cayman Chemical SB-258585hydrochlorIde 10mg
A potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals
Cayman Chemical BenzquInamIdehydrochLRIde 10mg
An antiemetic and antagonist of dopamine D2-, D4-, and D3 receptors (Kis = 1,365, 691, and 545 nM for α2A-, α2B-, and α2C-AR, respectively); has been mistakenly identified as an antagonist of histamine H1 receptors and M1-5 mAChRs; inhibits conditioned avoidance in the shuttle box test in dogs (ED50 = 2.77 mg/kg); inhibits apomorphine-induced emesis in dogs (ED50 = 0.69 mg/kg); induces tachycardia, increases blood levels of norepinephrine, and temporarily decreases systolic and diastolic blood pressure, which revert to baseline within one minute in normotensive dogs at 0.5-5 mg/kg
Cayman Chemical CeramIdenon-hydroxybovIn 10mg
A mixture of non-hydroxy fatty acid-containing ceramides
Cayman Chemical NordeoxycholIc AcId 10mg
A metabolite of norcholic acid and derivative of deoxycholic acid; hepatic levels are decreased in rats in a high-fat diet model of NAFLD; serum levels are lower in men compared with women; has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS
Cayman Chemical Cefmetazole 10mg
A cephamycin antibiotic; active against E. coli, P. mirabilis, H. influenzae, N. gonorrhoeae, S. pneumoniae, and S. pyogenes (MIC50s = 0.25-2 μg/ml); decreases the lesion size and the number of ulcerative lesions in a rabbit model of active syphilis at 20 and 40 mg/kg per day
Cayman Chemical 6-AmInophenthrIdIn 10mg
An antiprion agent; inhibits prion formation in yeast- and mammalian-based screening assays; inhibits protein folding activity of the ribosome at 300 µM; directly competes with protein substrates for the ribosome active site and decreases the yield of refolded protein without affecting the rate of refolding; prevents progressive wing position defects in a Drosophila model of OPMD at 300-400 µM in larvae and 1-3 mM in adults
Cayman Chemical PolygalacIc AcId 10mg
A triterpenoid saponin with antioxidant and neuroprotective activities; scavenges peroxyl and peroxynitrite radicals in TOSC assays from 25-200 µM; reverses scopolamine-induced memory deficits, decreases in hippocampal ACh levels, increases in hippocampal IL-1β and IL-10 levels, and decreases in brain SOD and GSH levels in mice at 3, 6, and 12 mg/kg
Cayman Chemical Nmethyl2AIhydrochLRIde 10mg
An AI that reduces nociception and inhibits exploratory in mice; intended for forensic and research purposes
Cayman Chemical IsochlortetracyclIn 10mg
An inactive alkaline degradation product of chlortetracycline; appears to be a product of in vivo chlortetracycline metabolism
Cayman Chemical NodInItIb-1 10mg
Selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability
Cayman Chemical 1PalmItoyl2Oleoyl3ArachI 10mg
A triacylglycerol; has been found in lipid extracts from whole rat retina
Cayman Chemical 18-methyl EIcosnoIc AcId 10mg
A main component of the outer layer of the epicuticle of human hair that is used as an additive to hair cosmetics due to its desirable conditioning effects